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本文报道血卟啉类新光敏剂癌光啉对犬急性、亚急性毒性的病理组织学观察结果。急性毒性主要表现为肝细胞有灶性气球样变性,大剂量还可致肝细胞、肾近曲小管变性、坏死及脑水肿。亚急性毒性的主要变化为肝枯氏细胞增生、肿大及空泡变性,严重时周围肝细胞受压萎缩;电镜观察见肿大的枯氏细胞浆内留有可能与药物有关的絮状物。此外,大剂量还出现肾管变性坏死及脑水肿等。上述改变与剂量相关,尚未见文献报道。病理学观察结果表明,癌光啉的临床推荐剂量(2.5～5.0mg/kg i.v.)是安全的,肝、肾功能检测及以AIP的常见症状和体征作为癌光啉临床应用的监护指标是合适和必要的。
This paper reports the hematoporphyrin new photosensitizer cancer photoprinting acute and subacute toxicological histopathological observations. Acute toxicity mainly manifested as hepatocellular focal balloon degeneration, high doses can also cause liver cells, renal proximal tubule degeneration, necrosis and cerebral edema. Subacute toxicity of the main changes of liver cell proliferation, swelling and vacuolar degeneration, severe compression of the surrounding atrophy of liver cells; electron microscopy showed that the cytoplasm of the cytoplasm of the cytoplasm may leave drug-related floc . In addition, high-dose also appeared degeneration and necrosis of the kidneys and brain edema. The above changes associated with the dose, has not been reported in the literature. The results of pathology showed that the recommended dose of carcinogenophenanthroline (2.5 ~ 5.0mg / kg iv) was safe, liver and kidney function tests and the common symptoms and signs of AIP as the monitoring indicators of clinical application of cancer photopheresis And necessary.