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目的 :探讨乙型肝炎病毒携带者妊娠对母婴的危害以及如何进行预防。方法 :用放射免疫方法对 865名孕妇产前检查两对半 ,并留其中 HBs Ag阳性者脐带血检查两对半 ;对 36名 HBs Ag阳性孕妇 ,产前 3个月开始注射乙肝免疫球蛋白 ( HBIG) ,每月一次 ,并对其新生儿血进行两对半检查。结果 :HBs Ag阳性孕妇比阴性者妊高征、产后出血、切口感染、宫内感染、HBV垂直感染、围产儿死亡率明显升高 ;但新生体重无显著差异 ;HBs Ag阳性孕妇注射 HBIG组的新生儿 HBV感染率较不注射组要低 ,差异显著。结论 :乙型肝炎病毒携带者妊娠对母体及婴儿危害较大 ,选择产前 3个月注射 HBIG是阻断 HBV宫内感染的措施之一
Objective: To investigate the harm of hepatitis B virus carriers during pregnancy to maternal and infant and how to prevent it. Methods: 865 pregnant women were examined by radioimmunoassay for two and a half days before their antenatal examination. Half of the HBsAg-positive cord blood samples were checked by two-and-a-half. For 36 HBsAg-positive pregnant women, hepatitis B immunoglobulin (HBIG) once a month, and check their neonatal blood for two and a half weeks. Results: HBsAg-positive pregnant women than HBsAg-positive pregnant women than pregnancy-induced hypertension, postpartum hemorrhage, incision infection, intrauterine infection, HBV vertical infection, perinatal mortality was significantly increased; but no significant difference in neonatal weight; HBsAg positive pregnant women injected with HBIG group Neonatal HBV infection rate was lower than non-injection group, the difference was significant. Conclusion: Pregnancy of hepatitis B virus carriers is more harmful to maternal and infant. One of the measures to block HBV intrauterine infection is to inject HBIG 3 months prenatal