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75只离乳雄性SD大鼠随机地分成对照、蔗糖和猪油组,分别用对照饲料、含10％蔗糖饲料和含20％猪油的高脂饲料饲养14周,观察高脂饲料致大鼠肥胖的作用。实验结果表明,猪油组大鼠体重、体脂含量以及附睾脂肪块和腹膜后脂肪块重量均大于对照和蔗糖组大鼠(P<0.001)。而且猪油组大鼠根据其体脂含量可分成DIO与DIO-R二类大鼠。DIO大鼠的体重、体脂含量、附睾脂肪块和腹膜后脂肪块重量分别为392.8±12.8克,34.96±0.64克/100克干体重,7.36±0.50克和8.74±0.50克。DIO-R、大鼠上述指标则分别为344.7±12.4克,24.13±0.61克/100克干体重,3.80±0.87克和3.24±0.28克。研究结果说明含20％猪油的高脂饲料对SD大鼠有致肥胖作用,而未能发现10％的蔗糖饲料有此作用。
Seventy-five male SD rats were randomly divided into control, sucrose and lard groups and fed with control feed, 10% sucrose diet and high fat diet containing 20% lard for 14 weeks to observe the rats with high fat diet. The role of obesity. The experimental results showed that the body weight, body fat content, weight of epididymal fat mass and retroperitoneal fat mass of the lard group rats were higher than those of the control and sucrose group rats (P<0.001). And the lard group rats can be divided into DIO and DIO-R type II rats according to their body fat content. The body weight, body fat content, epididymal fat mass and retroperitoneal fat mass of DIO rats were 392.8±12.8 g, 34.96±0.64 g/100 g dry weight, 7.36±0.50 g and 8.74±0.50 g, respectively. The DIO-R and rat indices were 344.7±12.4 g, 24.13±0.61 g/100 g dry weight, 3.80±0.87 g and 3.24±0.28 g, respectively. The results showed that high-fat diets containing 20% lard caused obesity in SD rats, but failed to find that 10% of sucrose feed had this effect.