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将乌头碱从大白鼠静脉输入,诱发心律失常,是迄今鉴定抗心律失常药物和研究心律失常的传统的动物模型,但该模型主要缺点是所诱发的心律失常类型多种多样,互相演变不稳定,不利于药物间的效价比较。我们将乌头碱溶液注入大白鼠心脏左室壁内,可诱发单一的室性心动过速,持续时间平均为38±17min,利多卡因抗室速有效率为71%,脑卡地平为68%,而生理盐水为0%。认为是鉴定抗心律失常药物和研究室速的较理想的模型。
Aconitine intravenous input from rats to induce arrhythmia, so far identification of anti-arrhythmic drugs and the study of arrhythmia in the traditional animal model, but the main drawback of this model is the type of arrhythmia induced evolvement is not Stable, is not conducive to drug potency comparison. Aconitine solution we injected into the left ventricular wall of rats, can induce a single ventricular tachycardia, the average duration of 38 ± 17min, lidocaine effective rate of anti-ventricular 71%, brain card for the flat 68 %, While normal saline is 0%. It is considered as a more ideal model to identify antiarrhythmic drugs and laboratory velocity.