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观察两种HFRS灭活疫苗在陕西省高发病区接种后第2年的免疫效果。方法：于加强免疫前及免疫后14天、1年采集接种者静脉血，应用微量细胞病变法和荧光法检测中和抗体、IgG抗体，并观察流行病学防病效果。结果：鼠脑纯化灭活疫苗（Ⅰ型）加强免疫1年后，中和抗体阳性率为45％，GMT5．41，接种组无发病者，而对照组发病率为79．10／10万，保护率100％；沙鼠肾灭活疫苗（Ⅰ型）中和抗体阳性率40％，GMT50，接种组发病率6．02／10万，对照组发病率108．41／10万，保护率94．45％。两种疫苗均末发现免疫增强反应。
To observe the immune effects of two HFRS inactivated vaccines in the second year after inoculation in high-incidence areas in Shaanxi province. Methods: Venous blood was collected before immunization and at 14 days and 1 year after vaccination. Neutrophil antibody and IgG antibody were detected by microcytosis and fluorescence. The epidemiological and preventive effects were also observed. Results: The positive rate of neutralizing antibody was 45% at 1 year after booster immunization (type Ⅰ). The positive rate of neutralizing antibody was 45% in GMT5.41. The incidence rate of control group was 79.10 / 100000, The protection rate was 100%. The neutralizing antibody positive rate of gerbil kidney inactivated vaccine (type I) was 40%, GMT50, the inoculation group incidence was 6.02 / 100000, the control group incidence was 108.41 / 100000, the protection rate was 94 .45%. Both vaccines found no immune-enhancing response.