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【目的】分析醋酸钙联合骨化三醇冲击治疗继发性甲状旁腺功能亢进（HPT ）的临床效果。【方法】将本院2007年1月至2013年12月收治的109例慢性肾功能衰竭血液透析继发HPT患者，随机分为观察组（56例）及对照组（53例），两组患者均接受骨化三醇冲击治疗，并分别加用醋酸钙、碳酸钙治疗。观察组患者根据 HPT 病情分为中度 HPT 组（29例）及重度HPT组（27例），比较各组患者治疗前后血钙、磷、钙磷乘积及甲状旁腺激素（iPTH）水平，并观察其疗效及不良反应。【结果】观察组与对照组患者血清钙、磷及钙磷乘积均在治疗后4周显著上升，8～24周显著下降并于24周时恢复治疗前水平，其血清iPT H自治疗开始呈显著下降状态，观察组下降程度更为明显（ P ＜0．05）；中度HPT组与重度 HPT组患者治疗期间血清钙、磷、钙磷乘积均存在上升情况，在治疗24周后恢复治疗前水平，中度 HPT 组与重度 HPT 组患者治疗期间血清iPT H均持续下降，中度 HPT组最终降至（194±120）pg／mL ，重度 HPT组最终降至（402±101）pg／mL（ P ＜0．05）；观察组与对照组治疗有效率分别为94．6％、86．8％，观察组临床疗效显著优于对照组，且两组相比较差异有显著性（ P ＜0．05）；观察组与对照组治疗期间均未见抽搐、低血压、心律失常等不良反应发生，部分患者出现一过性血磷升高，在暂停使用药物后均有效恢复，对照组患者出现4例（7．5％）高钙血症，经对症治疗后好转。【结论】醋酸钙联合骨化三醇冲击治疗能够有效调节继发性 HPT患者血钙、血磷水平，降低其iPT H浓度，疗效显著，且治疗期间不良反应发生率较低，具有良好的安全性，是继发性 HPT 良好的临床治疗手段。“,”Objective]To explore the efficacies of calcium acetate plus calcitriol in the treatment of dialysis patients with secondary hyperparathyroidism (HPT) .[Methods]From January 2007 to December 2013 ,109 cases of HPT secondary to dial‐ysis were randomized divided into observation ( n=56) and control ( n=53) groups .Both groups received ossification in three alcohols shock plus calcium acetate or calcium carbonate respectively .And the observation group was further assigned into moderate HPT ( n =29) and severe HPT ( n =27) groups .Before and after treatment ,the serum levels of calcium ,phos‐phorus ,calcium phosphorus product and parathyroid hormone (iPTH) were observed and compared for all groups .And the ef‐ficacies and adverse reactions were recorded .[Results]In both observation and control groups ,the serum levels of calcium , phosphorus and calcium‐phosphorus product significantly increased within 4 weeks after treatment ,decreased greatly during 8~24 weeks and later returned to the pre‐treatment level .There was a significant reduction in the serum level of iPTH and it decreased more in observation group ( P<0 .05);In moderate and severe HPT groups ,the serum levels of calcium ,phosphor‐us and calcium‐phosphorus product increased and reverted before 24 weeks;in moderate and severe HPT groups ,the serum level of iPTH continued to decline .The moderate HPT group eventually declined to (194+120) pg/mL while severe HPT group dropped finally to (402+101) pg/mL ( P <0 .05);The curative rate of observation group was significantly better than that of control group (94 .6% vs 86 .8% );Neither group had an onset of convulsion ,hypotension or cardiac arrhythmia .Some patients experienced a transient elevation of blood phosphorus .Upon drug withdrawal ,all recovered effectively .In control group ,4 cases (7 .5% ) of hypercalcemia were relieved after symptomatic treatment .[Conclusion]With a definite efficacy ,the therapy of calcium acetate plus calcitriol can effectively regulate the blood levels of calcium and phosphorus of secondary HPT patients ,reduce the concentration of iPTH and lower the incidence of adverse reactions .