糖尿病肾病(DN)是糖尿病(DM)一种重要的慢性微血管病变并发症。临床观察发现用分子屏障修复药物治疗后,仍有部分DN患者蛋白尿不能逆转,分析可能还有其他的剩留影响因素,比如肾小球基底膜的电荷屏障损害。胰淀粉酶(PAM)和唾液淀粉酶(SAM)为同工酶,两者分子量和分子半径相同,等电点不同(PAM为7.0,SAM为5.9~6.4)。研究表明,应用两者清除率比值来 Diabetic nephropathy (DN) is an important complication of chronic microvascular disease of diabetes mellitus (DM). Clinical observation found that after the molecular barrier repair drug treatment, there are still some patients with DN proteinuria can not be reversed, the analysis may have other residual factors, such as the damage of the glomerular basement membrane charge barrier. Pancreatic amylase (PAM) and salivary amylase (SAM) are isoenzymes, both of which have the same molecular weight and molecular radius and different isoelectric point (PAM is 7.0 and SAM is 5.9-6.4). Research shows that the ratio of the two clearance rates is used