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目的探讨血清可溶性Fas蛋白(sFas)及肿瘤坏死因子-α(TNF-α)在慢性阻塞性肺疾病(COPD)发病中的作用及临床意义。方法符合COPD诊断标准的急性加重期与稳定期患者各68例,健康对照组20例,采用酶联免疫吸附试验(ELISA)测定血清sFas与TNF-α的水平。结果①COPD急性加重期血清sFas及TNF-α水平与稳定期及对照组比较显著升高(P<0.01);②急性加重期重度COPD血清sFas及TNF-α水平较中度COPD显著升高(P<0.05);③COPD急性加重期血清sFas及TNF-α水平与气流受限指标第一秒用力呼气容积(FEV1)呈负相关(r值分别是-0.256、-0.364,P均<0.05)。结论sFas及TNF-α通过抑制细胞凋亡参与COPD病理损伤,sFas及TNF-α可作为判定COPD严重程度的参考指标。
Objective To investigate the role and clinical significance of serum soluble Fas protein (sFas) and tumor necrosis factor-α (TNF-α) in the pathogenesis of chronic obstructive pulmonary disease (COPD). Methods Sixty-eight patients with acute exacerbation and stable disease and 20 healthy controls were enrolled in this study. Serum levels of sFas and TNF-α were measured by enzyme linked immunosorbent assay (ELISA). Results ① The levels of sFas and TNF-α in serum of patients with acute exacerbation of COPD were significantly higher than those of the control group (P <0.01); ② The serum levels of sFas and TNF-α in patients with severe exacerbation of COPD were significantly higher than those in moderate COPD (P < <0.05). ③The levels of sFas and TNF-α in acute exacerbation of COPD were negatively correlated with FEV1 (r = -0.256, -0.364, P <0.05, respectively). Conclusion sFas and TNF-α are involved in the pathological changes of COPD by inhibiting apoptosis, and sFas and TNF-α may be used as reference indexes for judging the severity of COPD.