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目前已普遍认为牛磺酸可能是中枢神经系统中的一种抑制性神经递质或神经调质。本实验的目的在于观察牛酸是否使背根神经节神经元膜产生电位变化及其是否对GABA引起的背根神经节神经元膜去极化有调制作用。应用细胞内记录技术观察，标本灌流液中滴加牛磺酸（0．1～100μmol／L）未记录到可检测的膜电位改变，但牛磺酸对GABA（0．3～1000μmol／L）引起的去极化有明显的抑制作用，并对GABAA受体特异性激动剂muscimol（10～100μmol／L）和isoguvacine（10～100μmol／L）引起的去极化有同样的抑制作用，此作用具有明显的浓度依赖性。如10μmol／L的牛磺酸可使100μmol／LGABA引起的去极化抑制47．2％±13．8％（n=8）。牛磺酸对GABA引起去极化的抑制作用随预加牛磺酸与外加GABA之间间隔时间的延长而逐渐减弱，约间隔8～10min，GABA引起的去极化完全恢复。结果提示，牛磺酸在脊髓背角信息传递中起重要的调制作用。
It is now generally accepted that taurine may be an inhibitory neurotransmitter or neuromodulator in the central nervous system. The purpose of this experiment was to observe whether taurine changes the membrane potential of dorsal root ganglion neurons and whether it modulates GABA-induced membrane depolarization of dorsal root ganglion neurons. Intracellular recording technique was used to observe the changes of membrane potentials of taurine (0.1 ~ 100μmol / L) in the perfusate. However, the effect of taurine on GABA (0.3 ~ 1000μmol / L) Induced depolarization and inhibited the depolarization induced by GABAA receptor specific agonists muscimol (10 ~ 100μmol / L) and isoguvacine (10 ~ 100μmol / L) With a significant concentration-dependent. Such as 10μmol / L of taurine can be 100μmol / LGABA induced depolarization inhibition of 47.2% ± 13.8% (n = 8). The inhibitory effect of taurine on GABA-induced depolarization decreased gradually with the increase of the interval time between preadipose taurine and GABA plus GABA-induced depolarization restored at intervals of 8-10 min. The results suggest that taurine plays an important modulatory role in the transmission of spinal dorsal horn.