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代谢性心血管病是以机体糖类或脂质代谢紊乱为主要病因的一类心血管疾病,其中2型糖尿病又是典型的代谢性疾病,它不仅会使人产生胰岛素抵抗,更与动脉粥样硬化有关。由活性氧/活性氮产生的氧化应激是引起动脉粥样硬化的一个重要因素,而线粒体不仅是活性氧/活性氮的来源,更是其作用靶点,现有证据表明,线粒体功能障碍是导致心血管损伤的一种机制。文章从活性氧/氮所引发的线粒体功能障碍入手,介绍了二者过量后所激发的线粒体凋亡通路对动脉粥样硬化的影响,就二者通过影响脂质代谢及诱发2型糖尿病,继而产生心血管疾病做一综述,并介绍了麦冬、紫铆亭、人参、葛根和白毛藤等数味中药通过抗ROS/RNS及影响线粒体凋亡通路,从而达到治疗作用。而且以上诸味中药还有诸如抗癌和抗疲劳等作用,有别于经典西药作用的单一性,显示了中药作用的多面性。
Metabolic cardiovascular disease is a type of cardiovascular disease with the main cause of carbohydrate or lipid metabolism disorders. Type 2 diabetes is a typical metabolic disease. It not only causes insulin resistance but also causes atherosclerosis Related to hardening. Oxidative stress caused by reactive oxygen species / active nitrogen is an important factor that causes atherosclerosis. Mitochondria are not only the source of reactive oxygen species and active nitrogen, but also the target of their action. The available evidence shows that the mitochondrial dysfunction is A mechanism that causes cardiovascular damage. The article starts from the mitochondrial dysfunction induced by ROS / N and introduces the effect of mitochondrial apoptotic pathways on the atherosclerosis induced by overdose. The effect of both on lipid metabolism and type 2 diabetes, It also introduced the effects of Radix Astragali, Ziwei Pavilion, ginseng, Pueraria lobata and other white Chinese herbs on anti-ROS / RNS and mitochondrial apoptotic pathways. And more than all the flavor of traditional Chinese medicine such as anti-cancer and anti-fatigue and other functions, different from the uniqueness of the role of classic Western medicine, showing the versatility of traditional Chinese medicine.