癌胚抗原(CEA)可由多种癌细胞分泌产生,是作为诊断恶性肿瘤有价值的工具。1965年,Cold和Freedman率先从结肠腺癌提取物中鉴定了这种抗原。这种大分子糖蛋白含特异性抗原决定簇,并具有典型的化学、免疫学特性。除了结肠腺癌外,已发现许多肿瘤:如乳腺、前列腺、卵巢、腮腺及小唾液腺肿瘤,也都能分泌CEA。免疫组化技术的发展已能用制备的特异 Carcinoembryonic antigen (CEA) is secreted by a variety of cancer cells and is a valuable tool for diagnosing malignant tumors. In 1965, Cold and Freedman pioneered the identification of this antigen in colon adenocarcinoma extracts. This macromolecular glycoprotein contains specific antigenic determinants and has typical chemical and immunological properties. In addition to colon adenocarcinoma, many tumors have been found: breast, prostate, ovarian, parotid, and small salivary gland tumors, as well as CEA. The development of immunohistochemistry has enabled the preparation of specificity