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采用过氧乙酸法使~(125)I标记放射增敏剂MISO,标记率大于80％,高时达90％以上。研究了~(125)I-MISO在动物体内的组织分布,结果显示在静脉注射后3小时,H_(22)荷瘤鼠及EMT-6荷瘤鼠的肿瘤/血液比分别是1.09与1.00。活体闪烁显像及放射自显影均显示肿瘤区有部分放射性浓聚,但不及肝、肺、肠等组织明显。
Radioactive acetic acid was used to label ~(125)I radiosensitizer MISO with a labeling rate of more than 80% and a high rate of 90%. The tissue distribution of ~(125)I-MISO in animals was studied. The results showed that the tumor/blood ratio of H22 tumor bearing mice and EMT-6 tumor bearing mice was 1.09 and 1.00 respectively at 3 hours after intravenous injection. Live scintigraphy and autoradiography showed that some of the radioactivity concentrated in the tumor area, but not as obvious as liver, lung, intestine and other tissues.