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目的探讨脑苷肌肽注射液对新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将青海格尔木人民医院儿科2009年1月至2012年11月治疗的120例HIE患儿随机分为治疗组(60例)和对照组(60例),两组均给予常规治疗,治疗组在常规治疗基础上加用脑苷肌肽注射液每天2ml加入5%葡萄糖50ml中静脉滴注,对照组在常规治疗基础上加用胞二磷胆碱125mg,1次/日。结果治疗组总有效率90%,对照组总有效率67.8%,差异有统计学意义(P<0.05)。治疗组症状恢复时间较对照组平均缩短1.6d,差异有统计学意义(P<0.05)。结论脑苷肌肽注射液对HIE患儿有较好疗效,值得临床推广应用。
Objective To investigate the clinical effect of emanganoside on neonatal hypoxic-ischemic encephalopathy (HIE). Methods One hundred and twenty children with HIE treated in Qinghai Golmud People’s Hospital from January 2009 to November 2012 were randomly divided into treatment group (60 cases) and control group (60 cases). Both groups were given routine treatment. On the basis of conventional treatment, 2mg of 5% glucose was added to 2ml daily, and the control group was treated with citicoline 125mg once a day on the basis of routine treatment. Results The total effective rate was 90% in the treatment group and 67.8% in the control group, the difference was statistically significant (P <0.05). The symptom recovery time of the treatment group was 1.6 days shorter than that of the control group on average, the difference was statistically significant (P <0.05). Conclusion Eosinoside injection has a good effect on children with HIE, which is worthy of clinical application.