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目前已生产的治疗用药用酶已有50几种,载入马丁代尔大药典的有30多种。有助消化、抗炎、清疮祛痰、护肝、溶血栓、止血、抗过敏、抗肿瘤等八大类作用。蛋白酶用于医药历史悠久,初期一般由动植物中获取,蛋白酶用于抗炎剂亦有多年,自六七十年代以来,特别是日本广泛开展了微生物蛋白酶的研究并用于临床。七十年代起中科院微生物所也开展了抗炎蛋白酶研究,从工业用枯草杆菌蛋白酶中制取了药用中性蛋白酶。山东沂蒙新华制药厂在中科院微生物所的基础上,完成了口服中性蛋白酶
At present, there are 50 kinds of therapeutic pharmaceutical enzymes that have been produced, and there are more than 30 kinds of enzymatic enzymes in the Martindale Pharmacopoeia. It can help digestion, anti-inflammation, clear sores, liver protection, thrombolysis, hemostasis, anti-allergy, anti-tumor and other eight types of effects. Proteases have a long history of use in medicine. They were generally obtained from animals and plants in the early stages, and proteases have been used for anti-inflammatory agents for many years. Since the 1960s and 1970s, the research on microbial proteases has been extensively carried out in Japan and has been used clinically. In the 1970s, the Institute of Microbiology, Chinese Academy of Sciences also carried out research on anti-inflammatory proteases, and made medicinal neutral proteases from industrial subtilisin proteases. Shandong Yimeng Xinhua Pharmaceutical Factory completed an oral neutral protease based on the Institute of Microbiology, Chinese Academy of Sciences.