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[目的]探讨子宫切除术对难治性功能性子宫出血患者生活质量的影响因素.[方法]收集2008年1月至2015年3月在本院行子宫切除术的250例难治性功能性子宫出血患者为研究对象(观察组),选择同期健康体检正常妇女100例为对照组,比较两组性生活质量及性功能指数(FSFI)情况,并以出院后2年生活质量差为终末事件,单因素及Logistic多因素回归分析影响患者生活质量的相关因素.[结果]观察组术后3个月生活质量总分、FSFI总分分别为(121.58±19.52)分、(60.90±11.34)分,均明显低于对照组(151.67±20.45)分、(75.19±12.48)分,其差异有统计学意义(P<0.05);患者出院后2年生活质量差112例,占44.80%,生活质量良138例,占55.20%.Logistic多因素回归显示年龄≥50岁为子宫全切除术患者出院后2年生活质量差的独立危险因素(OR=1.256).[结论]子宫切除术对难治性功能性子宫出血患者性功能及性生活质量造成不良影响;年龄大于50岁是影响患者术后2年生活质量的独立因素.“,”[Objective]To investigate the effect of hysterectomy on quality of life of patients with refractory functional uterine bleeding.[Methods]A total of 250 cases of patients with refractory functional uterine bleeding (observation group) who were treated by hysterectomy during January 2008 to March 2015 were selected as the observation group and 100 normal healthy women (the control group) were enrolled in the study.The Female Sexual Function Index (FSFI) was compared between the two groups.Poor quality of life in 2 years after discharge was taken as the terminal event,and the related factors influencing the quality of life were analyzed by univariate and multivariate Logistic regression analysis.[Results]The total score of quality of life and total score of FSFI in the observation group were significantly lower than those in the control group in 3 months after operation [(121.58±19.52) vs (151.67±20.45) and (60.90±11.34) vs (75.19±12.48)](P<0.05).There were 112 cases (44.80%) marked poor quality of life and 138 cases marked good quality of life in 2 years after discharge.Multivariate Logistic regression analysis showed that age ≥50 years old was the independent risk factor for poor quality of life of patients underwent hysterectomy in 2 years after discharge (OR=1.256).[Conclusion]Hysterectomy has adverse effect on the sexual function and quality of sexual life of patients with refractory functional uterine bleeding;age over 50 years is an independent factor affecting the quality of life after 2 years of surgery.