Tamm和Horsfall最先分离并描述了一种尿内糖蛋白,这种蛋白显示出是一种病毒血细胞凝集反应的强的抑制剂。一般称之为Tamm—Horsfall糖蛋白(简称TH)。它是尿内管型的最初成分。用免疫荧光法研究,TH似乎存在于所有肾小管细胞的胞浆内。作者进一步用辣根过氧化酶标记抗正常鼠肾内TH抗体,通过免疫电镜来研究TH所存在的部位,并与TH的免疫荧光以及免疫过氧化酶光学显微镜的形态学定位进行了比较。通过电子显微镜发现:TH仅限于享利氏襻升支的粗段细胞内。在这些细胞内,TH位于邻接的细胞间膜之上及其之间,这些细胞底部的皱折的细胞内的膜上、高尔基氏小泡、顶端 Tamm and Horsfall first isolated and described a urinary glycoprotein that appears to be a potent inhibitor of the viral hemagglutination. Generally known as Tamm-Horsfall glycoprotein (referred to as TH). It is the first component of urinary tube type. Using immunofluorescence studies, TH appeared to be present in the cytoplasm of all tubular cells. The authors further used horseradish peroxidase anti-normal mouse renal TH antibody labeled by immunoelectron microscopy to study the existence of TH site, and immunoflurescence immunofluorescence and immunoperoxidase optical microscopy Morphological mapping were compared. Electron microscopy revealed that TH was restricted to the rudimentary cells of the Thalidomide. Within these cells, TH is located on and between adjacent intercellular membranes, the membrane within the crumpled cells at the base of these cells, the Golgi vesicles, the apical