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目的分析我院嗜麦芽窄食单胞菌的流行分布及耐药现状，为临床合理选择抗菌药物提供依据。方法分离、培养、鉴定2008-2010年临床的嗜麦芽窄食单胞菌。药敏试验采用纸片扩散法，数据分析采用WHONET 5.6软件。结果我院嗜麦芽窄食单胞菌2008-2010年检出数为151株(2.4%)、251株(3.4%)、374株(4.1%)；嗜麦芽窄食单胞菌除对头孢哌酮舒巴坦、左氧氟沙星和复方新诺明的敏感率较高，对其他抗菌药物的敏感率均较低。结论嗜麦芽窄食单胞菌我院检出逐年增加。嗜麦芽窄食单胞菌表现为高度和多重耐药性，应加强其耐药性的监测，合理选择有效的抗菌药物。“,” Objective To analyze the clinical distribution and drug resistance of Stenotrophomonas maltophilia in our hospital and to provide a basis for the clinical rational use of antibiotics.Method Stenotrophomonas maltophilia was isolated,cultured and identified from 2008 to 2010. Drug susceptibility test was performed by disk diffusion method,and data were analyzed using WHONET 5.6.Results The isolates of Stenotrophomonas maltophilia from 2008 to 2010 years were 151(2.4%),251(3.4%),374(4.1%).Al antibiotics showed low sensitivity to Stenotrophomonas except that cefoperazone sulbactam,levofloxacin and cotrimoxazole showed high sensitivity. Conclusion Stenotrophomonas maltophilia increased year by year and showed high and multi-drug resistance.We should strengthen its monitoring of drug resistance and choose the effective antibiotics.