目的研究CD133及血管内皮生长因子(VEGF)在乳腺癌组织中的表达及其意义。方法采用免疫组织化学方法检测109例乳腺癌组织中的CD133及VEGF的表达,并对结果进行分析。结果乳腺癌组织中CD133和VEGF蛋白的表达率分别是46.8%(51/109)和84.4%(92/109),其阳性表达率随肿瘤病理级别的升高而明显增加(P<0.05)。乳腺癌Basal-like亚群中CD133蛋白的阳性率表达高达69.2%,高于其他亚群(P<0.05)。CD133与VEGF表达密切相关(P<0.01)。结论CD133与VEGF蛋白表达可能与乳腺癌肿瘤干细胞生长有关。 Objective To study the expression of CD133 and vascular endothelial growth factor (VEGF) in breast cancer and its significance. Methods Immunohistochemistry was used to detect the expression of CD133 and VEGF in 109 cases of breast cancer and the results were analyzed. Results The positive rates of CD133 and VEGF in breast cancer tissues were 46.8% (51/109) and 84.4% (92/109), respectively. The positive rates of CD133 and VEGF were significantly increased with the increase of tumor pathological grade (P <0.05). The positive rate of CD133 protein in Basal-like subgroup of breast cancer was 69.2%, which was higher than other subgroups (P <0.05). CD133 expression is closely related to VEGF (P <0.01). Conclusion CD133 and VEGF protein expression may be related to the growth of breast cancer stem cells.