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目的探讨WNT5A基因rs566926位点多态性与中国苏皖地区部分人群非综合征性唇腭裂的相关研究。方法选取100例非综合症性唇腭裂(NSCLP)患儿为实验组,100例正常儿童作为对照组,应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测WNT5A基因rs566926多态性。采用病例对照研究方法进行统计分析并依据临床病理类型进行分类分析。结果两组基因型频数分布有明显差异(P<0.05)。结论 WNT5A基因rs566926位点多态性与中国苏皖地区部分人群NSCLP的发生有相关性,可能是该人群NSCLP发生的易感因素之一。
Objective To investigate the relationship between rs566926 polymorphism of WNT5A gene and non-syndromic cleft lip and palate in some population of Jiangsu and Anhui provinces. Methods One hundred children with NSCLP were selected as experimental group and 100 normal children as control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect WNT5A gene rs566926 polymorphism. Case-control study was used for statistical analysis and classified according to the type of clinical pathology. Results There was a significant difference in the frequency distribution of genotype between the two groups (P <0.05). Conclusion The rs566926 polymorphism of WNT5A gene is associated with the occurrence of NSCLP in some patients in Jiangsu and Anhui Provinces, which may be one of the predisposing factors for NSCLP in this population.