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氨基糖苷类抗生素从1944年发现链霉素之日起就构成了一个主要的治疗剂种类,现已含有200多种天然化合物。所有这些抗生素都含有一个环多醇配基和连接着氨基糖的糖苷键,氨基糖苷类根据其结构和环多醇部分取代的方式详细区分。确切地说,属于所有氨基糖苷类不同亚类的抗生素已经发现了很大的应用范围,因此发现一个新氨基糖苷类品种比其它抗生素可能有更高的应用价值。尽管它们关系到对人体的毒性,氨基糖苷类还是广泛地应用于人和兽的治疗以及应用于农业上。由于氨基糖苷类抗菌谱广,尚没有其它抗生素品种具有这样广泛抗致病菌作用的范围。
Aminoglycosides constitute a major therapeutic group since the discovery of streptomycin in 1944 and now contain more than 200 natural compounds. All of these antibiotics contain a cyclic polyol ligand and glycosidic linkages linked to aminosugars, which are distinguished in detail by their structure and the partial substitution of the cyclic polyol. Specifically, antibiotics belonging to all the different subgroups of aminoglycosides have been found to have a wide range of applications and it is therefore found that a new aminoglycoside variety may have higher value than other antibiotics. Although they are related to human toxicity, aminoglycosides are widely used in the treatment of humans and animals as well as agricultural applications. Because of the broad antibacterial spectrum of aminoglycosides, no other antibiotic species has such a wide range of anti-pathogenic effects.