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芋螺睡眠肽是一类与众不同的芋螺毒素,一级结构有高度同源性,它含有丰富的γ-羧基谷氨酸,和其他类芋螺毒素不同的是一般不含二硫键(除了芋螺睡眠肽-R),在结合金属离子后,构像中α-螺旋结构的成分会有不同程度地增加。芋螺睡眠肽是一类非竞争性的N-甲基-D-天门冬氨酸(N-methyl-D-aspartate,NMDA)受体的选择性抑制剂,并且具有受体亚型特异性,颅内注射芋螺睡眠肽后,实验鼠会呈现一种睡眠样症状。序列及结构分析显示,正是芋螺睡眠肽序列中高度保守的氨基酸残基决定了它们的结构及功能,文中对其结构和功能的关系作了综合分析。
The conotoxin sleeping peptide is a distinctive conotoxin with a high degree of primary structure homology, which is rich in gamma-carboxyglutamate. Unlike other conotoxins, it is generally free of disulfide bonds (Except the taro sleep peptide-R), the composition of the α-helical structure in the conformation increases to some extent after the metal ions are bound. As a selective non-competitive inhibitor of N-methyl-D-aspartate (NMDA) receptors, the taro sleep peptide is characterized by its receptor subtype specificity, Intracranial injection of taro sleep peptide, the mice will show a kind of sleep-like symptoms. Sequence and structure analysis showed that it is the amino acid residues of the conos sleep peptide that determine their structure and function. The structure and function of the conotoxin were analyzed synthetically.