自从1950年Hanes 由羊肾提取出γ-谷氨酰基移换酶(γGT)后,逐渐发现γGT 广泛存在于哺乳动物组织中,其中活性最高的依次为肾、前列腺、睾丸、胰和肝脏。60年代许多人报道肝病时可有血清γGT 活性增高,尤以肝癌时为最明显,可高达正常值的数十倍。 Since Hanes extracted γ-glutamyl transferase (γGT) from goat kidneys in 1950, it has been found that γGT is widely found in mammalian tissues, with the highest activity being kidney, prostate, testis, pancreas and liver. In the 1960s, many people reported that liver gamma GT activity increased during liver disease, especially in liver cancer, which was as high as tens of times normal.