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转录因子叉头框Q1(forkhead box Q1,FOXQ1)是叉头框(forkhead box,FOX)超家族的成员之一,广泛存在于人体的多种组织和器官,参与胚胎干细胞和脊椎动物的发育过程。作为转录因子,FOXQ1蛋白通过作用于靶基因的启动子或与其他转录因子相互作用激活靶基因的转录,并从上皮-间质转化(epithelial-mesenchymal transition,EMT)和细胞信号转导等多方面影响肿瘤的发生、发展、侵袭和转移过程。鉴于FOXQ1与肿瘤具有明显相关性,其表达水平可作为某些肿瘤预后评估的指标,并有望成为肿瘤治疗的新靶点。本文通过综述最新文献,着重阐述了FOXQ1在肿瘤发生和发展过程中的作用及其可能的机制,以期为肿瘤治疗和研究提供一些参考。
Transcription Factor Q1 (FOXQ1) is a member of the forkhead box (FOX) superfamily and is widely present in many tissues and organs of the body and is involved in the development of embryonic stem cells and vertebrates . As a transcription factor, FOXQ1 activates the transcription of target genes by acting on the promoter of the target gene or by interacting with other transcription factors, and from the aspects of epithelial-mesenchymal transition (EMT) and cell signal transduction Affect the occurrence, development, invasion and metastasis of tumor. In view of FOXQ1 and tumor has obvious relevance, its expression level can be used as an indicator of some tumor prognosis, and is expected to become a new target for cancer treatment. This review summarizes the recent literature and focuses on the role of FOXQ1 in tumorigenesis and progression and its possible mechanism, so as to provide some references for tumor therapy and research.