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目的探讨CD55、CD59、RET%、N-ALP对阵发性血红蛋白尿(PNH)及AA-PNH的早期诊断的价值,寻找PNH及AA-PNH早期诊断敏感指标,进而达到早期发现、早期诊断、早期治疗的目的。方法应用流式细胞仪测定PNH综合征及AA-PNH患者的CD55、CD59抗原变化关系,RET%、N-ALP用细胞化学染色显微镜记数。结果结果表明PNH及AA-PNHCD55、CD59抗原较AA及正常对照组明显减低,AA转变为AA-PNH过程中RET%进行性增高,相反中性粒细胞NALP积分在此过程中呈进行性降低。结论CD55、CD59抗原表达率以及RET%、NALP可做PNH及AA-PNH早期诊断最敏感指标,同时并与预后转归密切相关。
Objective To investigate the value of CD55, CD59, RET% and N-ALP in the early diagnosis of paroxysmal hemoglobinuria (PNH) and AA-PNH, to find out the sensitive indexes for early diagnosis of PNH and AA-PNH and to achieve early detection, early diagnosis, early diagnosis The purpose of treatment. Methods The changes of CD55 and CD59 antigen in patients with PNH syndrome and AA-PNH were detected by flow cytometry. The percentage of RET% and N-ALP were counted by cytochemical staining. The results showed that PNH and AA-PNHCD55, CD59 antigen significantly lower than AA and normal control group, AA to AA-PNH into the process of RET% progressive increase, on the contrary neutrophil NALP integral in this process was progressively decreased. Conclusion The expression rates of CD55 and CD59, RET% and NALP are the most sensitive indicators for the early diagnosis of PNH and AA-PNH, and are closely related to prognosis.