Metabolic regulation by p53

来源 :世界最新医学信息文摘 | 被引量 : 0次 | 上传用户:qq591570317
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
We are increasingly aware that cellular metabolism plays a vital role in diseases such as cancer, and that p53 is an important regulator of metabolic pathways. By transcriptional activation and other means, p53 is able to contribute to the regulation of glycolysis, oxidative phosphorylation, glutaminolysis, insulin sensitivity, nucleotide biosynthesis, mitochondrial integrity, fatty acid oxidation, antioxidant response, autophagy and m TOR signalling. The ability to positively and negatively regulate many of these pathways, combined with feedback signalling from these pathways to p53, demonstrates the reciprocal and flexible nature of the regulation, facilitating a diverse range of responses to metabolic stress. Intriguingly, metabolic stress triggers primarily an adaptive( rather than pro-apoptotic) p53 response, and p53 is emerging as an important regulator of metabolic homeostasis. A better understanding of how p53 coordinates metabolic adaptation will facilitate the identification of novel therapeutic targets and will also illuminate the wider role of p53 in human biology. By are transcriptional activation and other means, p53 is able to contribute to the regulation of glycolysis, oxidative phosphorylation, glutaminolysis , insulin sensitivity, nucleotide biosynthesis, mitochondrial integrity, fatty acid oxidation, antioxidant response, autophagy and m TOR signaling. The ability to positively and negatively regulate many of these pathways, combined with feedback signaling from these pathways to p53, demonstrates the reciprocal and flexible Nature of the regulation, facilitating a diverse range of responses to metabolic stress. Intriguingly, metabolic stress triggers for an adaptive (rather than pro-apoptotic) p53 response, and p53 is emerging as an important regulator of metabolic homeostasis. p53 coordinates metabolic adaptation will facilitate the identification of novel therapeutic targets and will also illuminate the wider role of p53 in human biology.
其他文献
刘韶军,郑州大学建筑学院副教授、硕士生导师,2005年河南省教育厅学术技术带头人。1992年7月,刘韶军毕业于郑州工学院建筑设计及其理论 Liu Shaojun, associate professor a
新生儿尿布疹是新生儿常见的皮肤病 ,是指尿布覆盖部位皮肤潮红、糜烂、皮疹 ,如果不及时治疗 ,可迁延不愈 ,并可继发皮肤感染。笔者采用珍珠粉外治本病 ,取得满意疗效 ,现介
首先从网络拓扑结构、网络通信协议两方面,在比较各种方案的基础上论述了FMS网络通信子系统的设计,然后论述了网络系统的实施,并对所采用的软硬件平台和编程方法作了说明。 First
奶奶家有一只大公鸡,它身上的羽毛乌黑发亮,而尾巴是彩色的,总是高高翘起,就像挥动着的彩旗。它头上的鸡冠又大又红,民间俗话说:吃鸡冠当大官。那么大的鸡冠,吃了少说也可以
金秋十月,四川建筑职业技术学院(下称“四川建院”)迎来60岁“生日”。经过半个多世纪的办学砥砺,作为公办全日制高等院校的四川建院,秉承“建德明志,筑能笃行”的校训,确立
音乐的天空一颗巨星陨落,2008年6月16日15时,音乐大师时乐濛与世长辞。有些日子没看到时老了,很是想念。2008年灯节音乐界大聚会,在人民大会堂隆重举行。“时老来了——”中
姓名:许晓军单位:中山大学附属中山医院职务:内科教研室副主任、血液内科及输血科主任职称:主任医师、教授课题:血液系统恶性肿瘤、各种血栓及出血性疾病、再生障碍性贫血、
1977年,美国发射了“旅行家”号太空探测船。探测船里放有一张使用10亿年也嘹亮如新的唱片,唱片中录有30种声音,代表着人类向“外星人”的问候,其中有7段音乐,第2段就是巴赫
想象是一种创造力,创造就是源于想象,没有想象,创造就是空谈,古今中外的大科学家,在他们的科学创造中,都不乏想象,小学语文教学中,学生的想象力得到催生和发展,对学生参与其
患者,男,20岁。于1992—03—24来我院就诊,主诉;鼻阻塞,右眼球突出3年左右,近期加重。检查:外鼻无畸形,鼻粘膜正常;在鼻腔未见异常改变,通畅。右侧鼻腔后段可见肿物,表面光