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目的:探讨糖皮质激素诱导的肿瘤坏死因子受体(glucocorticoid-induced tumor necrosis factor receptor,GITR)与变应性鼻炎(allergic rhinitis,AR)的关系。方法:采用实时荧光定量PCR方法检测变应性鼻炎未治疗组(n=23,男12例,平均年龄34岁)、临床缓解组(n=17,男8例,平均年龄31岁)及正常对照组(n=24,男11例,平均年龄28岁)外周血单个核细胞(peripheral blood mononuclear cell,PBMC)中GITR mRNA的相对表达水平。结果:变应性鼻炎未治疗组GITR mRNA相对表达水平明显高于变应性鼻炎临床缓解组和正常对照组(P<0.05,P<0.01),而变应性鼻炎临床缓解组GITR mRNA相对表达水平与正常对照组相比较,差异无统计学意义(P>0.05)。结论:GITR可能参与了变应性鼻炎的病理过程,具体机制有待进一步研究。
Objective: To investigate the relationship between glucocorticoid-induced tumor necrosis factor receptor (GITR) and allergic rhinitis (AR). Methods: Real-time PCR method was used to detect allergic rhinitis in untreated group (n = 23, 12 males and average age 34 years), clinical remission group (n = 17, 8 males, mean age 31 years) and normal The relative expression level of GITR mRNA in peripheral blood mononuclear cells (PBMC) of the control group (n = 24, 11 males and 28 years of age in average). Results: The relative expression level of GITR mRNA in allergic rhinitis untreated group was significantly higher than that in clinical remission group and normal control group (P <0.05, P <0.01), while the relative expression of GITR mRNA in allergic rhinitis group Compared with the normal control group, the difference was not statistically significant (P> 0.05). Conclusion: GITR may be involved in the pathological process of allergic rhinitis, the specific mechanism needs further study.