胸膜积液是恶性病变的常见并发症,至少有1/2的乳癌或肺癌患者,在病程的某一个时期发生胸膜积液。许多恶性胸膜积液患者可望生存数月甚至数年之久,故采用有效的姑息治疗,是很重要的。本文复习了恶性胸膜积液的治疗经验,强调采用胸管闭式引流合并氮芥局部注射的方法。临床资料包括133例恶性胸膜积液,其中21例为双侧。原发瘤均经组织学鉴定, Pleural effusion is a common complication of malignant lesions, at least 1/2 of patients with breast cancer or lung cancer, pleural effusion occurs during a certain period of time. Many patients with malignant pleural effusion is expected to survive for months or even years, so the effective palliative treatment is very important. This article reviewed the treatment experience of malignant pleural effusion, emphasizing the use of closed chest drainage with nitrogen mustard local injection method. Clinical data included 133 cases of malignant pleural effusion, of which 21 were bilateral. Primary tumors were histologically identified,