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乙二醇除作汽车发动机冷却系统的抗冻剂外,近年已在登月舱用作循环冷却剂。乙二醇急性中毒时往往死于代谢性酸中毒和肾功能衰竭;慢性中毒的主要表现为眼球震颤和意识丧失的反复发作。其代谢途径经乙二醇乙醛、羟基醋酸、二羟醋酸,再分解为草酸和二氧化碳;乙二醇和其中间代谢产物对肾小管上皮细胞有明显的毒性;尿中排出大量草酸钙,并沉积于肾小管内。慢性中毒时体内钙贮存及排放能导致有关元素的代谢改变,作者研究了钙、磷两元素的
In addition to ethylene glycol anti-freeze system for automotive engine cooling system, in recent years has been used as a circulating lunar module coolant. Acute poisoning of ethylene glycol often die of metabolic acidosis and renal failure; chronic poisoning is mainly manifested nystagmus and loss of consciousness repeated attacks. The metabolic pathway by ethylene glycol acetaldehyde, glycolic acid, glyoxylic acid, re-decomposition of oxalic acid and carbon dioxide; ethylene glycol and its intermediate metabolites of renal tubular epithelial cells were significantly toxic; urinary excretion of large amounts of calcium oxalate and deposition In the tubules. Chronic poisoning in vivo calcium storage and emissions can lead to metabolic changes in the elements, the authors studied the two elements of calcium and phosphorus