论文部分内容阅读
目的探讨2型糖尿病患者对磺脲类药物继发失效后的治疗方法。方法将对磺脲类药物继发失效的2型糖尿病患者133例,分为预混胰岛素70/30联合二甲双胍或拜糖平组;胰岛素联合文迪雅组;磺脲类联合中效胰岛素及二甲双胍或拜糖平组;诺和龙联合二甲双胍组;诺和龙联合文迪雅5个组。观察空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbA1c)、体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)、胰岛B细胞功能指数(HOMA-B)的改变。结果各组的观察指标均有明显改善,其中以用预混胰岛素加文迪雅组改善最为显著。
Objective To investigate the treatment of type 2 diabetes after secondary failure of sulfonylureas. Methods A total of 133 type 2 diabetic patients with secondary failure of sulfonylureas were divided into two groups: premixed insulin 70/30 combined with metformin or orally administered cisplatin, insulin combined with Avandia group, sulfonylurea combined with middle-acting insulin and metformin Or orally with sugar level group; Novolin and metformin group; Novolin and Avandia 5 groups. The changes of fasting plasma glucose (FPG), 2hPG, HbA1c, BMI, HOMA-IR and HOMA-B were observed. Results The observation indexes in each group were significantly improved, of which the use of premixed insulin plus wendiya group to improve the most significant.