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目的通过检测外周血中生长抑素(somatostatin,SST)、胰岛素样生长因子-1(insulin-like growth factors-1,IGF-1)的水平,探讨其与子痫前期发生的关系。方法采用酶联免疫吸附测定法检测2013年3月—2014年12月在本院分娩的90例孕妇外周血中SST、IGF-1的水平,正常对照组30例,子痫前期组60例,其中子痫前期组又分为轻度子痫前期组30例、重度子痫前期组30例。计量资料比较采用t检验,相关性分析采用Spearman等级相关分析,P<0.05为差异有统计学意义。结果 SST在子痫前期组与正常对照组水平分别为(41.9±5.4)、(21.3±5.6)ng/ml,两组比较差异有统计学意义(P<0.05),在重度子痫前期组与轻度子痫前期组水平分别为(47.6±4.8)、(36.2±6.1)ng/ml,重度组明显高于轻度组,对比差异有统计学意义(P<0.05)。IGF-1在子痫前期组与正常对照组水平分别为(90.3±17.9)、(211.0±36.1)ng/ml,子痫前期组较对照组明显降低,对比差异有统计学意义(P<0.05)。IGF-1在重度子痫前期组与轻度子痫前期组分别为(74.3±14.6)、(106.2±21.5)ng/ml,对比差异有统计学意义(P<0.05)。子痫前期组患者的血清SST与IGF-1呈负相关,对比差异有统计学意义(r=-0.476,P<0.05)。结论 SST、IGF-1水平变化可能导致子痫前期的发生,并且两者可能相互影响。
Objective To investigate the relationship between somatostatin (SST) and insulin-like growth factors-1 (IGF-1) levels in peripheral blood and preeclampsia. Methods The levels of SST and IGF-1 in peripheral blood of 90 pregnant women delivered from March 2013 to December 2014 in our hospital from March 2013 to December 2014 were measured by enzyme-linked immunosorbent assay (ELISA), 30 cases in normal control group, 60 cases in preeclampsia group, The preeclampsia group was divided into 30 cases of mild preeclampsia group and 30 cases of severe preeclampsia group. Measurement data were compared using t test, correlation analysis using Spearman rank correlation analysis, P <0.05 for the difference was statistically significant. Results The levels of SST in preeclampsia group and normal control group were (41.9 ± 5.4) and (21.3 ± 5.6) ng / ml, respectively, with significant difference between the two groups (P <0.05) The levels in mild preeclampsia group were (47.6 ± 4.8) and (36.2 ± 6.1) ng / ml respectively, which were significantly higher in severe group than in mild group (P <0.05). The levels of IGF-1 in preeclampsia group and normal control group were (90.3 ± 17.9) and (211.0 ± 36.1) ng / ml, respectively. The levels of IGF-1 in preeclampsia group and control group were significantly lower than those in control group ). The levels of IGF-1 in severe preeclampsia group and mild preeclampsia group were (74.3 ± 14.6) and (106.2 ± 21.5) ng / ml, respectively. The difference was statistically significant (P <0.05). Serum SST was negatively correlated with IGF-1 in patients with preeclampsia, the difference was statistically significant (r = -0.476, P <0.05). Conclusion The changes of SST and IGF-1 level may lead to the development of preeclampsia, and the two may affect each other.