Primary intraosseous liposarcoma was a rare and malignant tumor of the skeletal system. It originated from the intraosseous adipose tissue. Since the first case was reported in 1931, there were only dozens of cases reported at home and abroad now, without the unified standard for diagnosis and treatment. Recently, a patient with intraosseous dedifferentiated liposarcoma was adopted by our department. Neither recurrence nor metastasis had been detected for 2 months after surgery.