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目的观察舒芬太尼应用于小儿术后硬膜外自控镇痛(PCEA)效果及其对白细胞介素(IL)6和IL-10的影响。方法 60例手术患儿随机均分为两组:S组以舒芬太尼行PCEA;C组用强痛定1 mg/kg按需肌注。记录术后镇痛期间的视觉模拟疼痛评分(VAS)、生命体征和不良反应。检测术毕、术后12、243、6 h外周血IL-6、IL-10的含量。结果镇痛期S组的VAS疼痛评分明显低于C组(P<0.01),两组患儿生命体征稳定。术后12 h两组IL-6含量均较术毕升高(P<0.05),但S组明显低于C组(P<0.01);S组术后12 h的IL-10含量较术毕升高(P<0.05),而C组IL-10含量较术毕降低(P<0.01)。两组不良反应发生率均较低。结论舒芬太尼用于小儿PCEA镇痛效果好,不良反应少,并可减轻手术后的炎症反应。
Objective To observe the effect of sufentanil on postoperative epidural analgesia (PCEA) and its effect on interleukin (IL) 6 and IL-10 in children. Methods Sixty children undergoing surgery were randomly divided into two groups: group S received sufentanil PCEA; group C was given intramuscular injection of streptozotocin at 1 mg / kg. Visual analog pain scores (VAS), vital signs and adverse reactions during postoperative analgesia were recorded. The levels of IL-6 and IL-10 in peripheral blood were measured at 12,243 and 6 h after operation. Results The VAS pain score of S group was significantly lower than that of C group during the analgesic period (P <0.01). The vital signs of both groups were stable. The content of IL-6 in both groups increased 12 h after operation (P <0.05), but was significantly lower in group S than that in group C (P <0.01) (P <0.05), while the content of IL-10 in group C was lower than that in the control group (P <0.01). Adverse reactions in both groups were lower. Conclusions Sufentanil is effective in analgesia of pediatric PCEA with less adverse reactions and can reduce postoperative inflammatory reaction.