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从哺乳期开始建立缺锌幼鼠模型，采用电镜观察、神经生化和神经电生理等方法，观察饲料缺锌对幼鼠脑发育和学习记忆的影响并探讨其机理。结果如下：①缺锌组脑重、海马重及血清、海马锌含量均明显低于正常组。②缺锌组ＬＴＰ（ｌｏｎｇ－ｔｅｒｍｐｏｔｅｎｔｉａｔｉｏｎ）诱发率为０，其主动回避反应习得率明显低于ＬＴＰ诱发率为１００％的正常组。③大脑皮层及海马组织兴奋性和抑制性氨基酸以及谷氨酸、γ－氨基丁酸含量、海马一氧化氮含量缺锌组均明显高于正常组，而海马生长抑素含量及锥体细胞核ＤＮＡ含量则缺锌组明显低于正常组。④海马锥体细胞突触小泡较正常组减少。提示膳食缺锌明显影响幼鼠脑发育及功能。
Zinc deficiency rat model was established from the beginning of lactation. The effects of dietary zinc deficiency on brain development and learning and memory were observed by using electron microscope, neurobiochemistry and electrophysiology. The results are as follows: ① Zinc deficiency group, brain weight, hippocampus and serum, hippocampus zinc content were significantly lower than the normal group. (2) Long-termpotentiation induced rate was 0 in zinc-deficient group, and the learning acquisition rate of active avoidance reaction was significantly lower than that of normal group with LTP induction rate of 100%. ③ Excitability and inhibitory amino acids, glutamate, γ-aminobutyric acid content and nitric oxide content in the hippocampus were significantly higher in the hippocampus than those in the normal group, while the content of somatostatin in the hippocampus and nuclear DNA The content of zinc deficiency group was significantly lower than the normal group. ④ hippocampal pyramidal synaptic vesicles decreased compared with the normal group. Tip Zinc deficiency diet significantly affect the brain development and function of young rats.