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目的探讨被动吸烟对呼吸道微生态的影响的机制,为预防吸烟对机体健康的损害提供理论依据。方法采用模拟被动吸烟的方法,对健康Wistar大鼠进行大气污染,研究大鼠口咽部菌群污染前后的变化。结果被动吸烟前后大鼠口咽部的微生态菌群明显发生改变(P<0.5)。吸烟前与吸烟后相比致病菌如金黄色葡萄球菌、肺炎克雷伯菌等检出率明显增高(P<0.5),厌氧菌密度减少,随着被动吸烟时间的延长,细菌的密度呈上下波动,且厌氧菌菌群密度变化更为明显(P<0.5)。结论被动吸烟对大鼠口咽部有破坏作用,导致菌群发生改变,致病菌增多,是呼吸道疾病发病率升高的重要因素之一。
Objective To explore the mechanism of passive smoking on the respiratory microflora and to provide a theoretical basis for preventing smoking damage to the health of the body. Methods The healthy Wistar rats were subjected to air pollution simulating passive smoking to study the changes of rat oropharyngeal flora before and after contamination. Results Before and after passive smoking, the orogenic flora of oropharynx was significantly changed (P <0.5). Before smoking and smoking compared to the pathogenic bacteria such as Staphylococcus aureus, Klebsiella pneumoniae detection rate was significantly increased (P <0.5), reduced anaerobic bacteria density, with the passive smoking time, the density of bacteria Fluctuated up and down, and the density of anaerobic bacteria population was more obvious (P <0.5). Conclusion Passive smoking has a damaging effect on the oropharynx of rats, leading to the change of flora and the increase of pathogenic bacteria, which is one of the important factors of the increased incidence of respiratory diseases.