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本文考察了沉淀荧光法测定组织中喜树碱浓度的可行性。实验结果表明,沉淀荧光法测定组织中喜树碱具有简便、快速的特点,且该法的选择性较好;灵敏度较高。用沉淀荧光法测定静脉注射给药后血浆中药物浓度研究结果表明,静注给药喜树碱前体多相脂质体(A-CPT-p1)后,其血药浓度时间过程符合三隔室开放模型,其α、β、γ相的半衰期分别为9.0,66.0及644min;V_(?),Vd分别为4.4296×10~(-2)及0.2508L;AUC及CJ分别为19474μg·min/ml及2.70×10~(-4)l/min;MRT为22.8h.
This article examines the feasibility of sediment fluorescence determination of camptothecin concentration in the tissue. The experimental results show that, the precipitation fluorescence method for the determination of camptothecin in tissue is simple and rapid, and the selectivity of the method is better; the sensitivity is higher. The results of sedimentation fluorescence assay of plasma drug concentration after intravenous administration showed that the time course of plasma concentration of camptothecin precursor polyphasic liposome (A-CPT-p1) The half-lives of α, β and γ phases were 9.0, 66.0 and 644 min, V_ () and Vd were 4.4296 × 10 -2 and 0.2508 L, respectively. The AUC and CJ were 19474 μg · min -1, ml and 2.70 × 10 ~ (-4) l / min; MRT was 22.8h.