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大量流行病学研究表明,胆囊切除后引起结肠癌的危险性增加,尤其在近端结肠和妇女中.一些胆汁酸代谢的研究证实,胆囊切除患者的肠肝循环中二级胆汁酸增加.本研究旨在研究胆囊切除患者粪便中肌汁酸的质和量,从而了解结肠粘膜与胆汁酸的接触情况.方法:25名胆囊切除患者(男5人,女20人),平均60岁,胆囊切除术后间隔时间13.1±2.0年,平均14年.26名非胆囊切除患者(男12人,女4人),平均56岁.被研究者中无1人患肝胆疾病,除胆囊切除术外,无1人接受过胃肠道手术.患者均进医院正规次食,每日平均提供30cal/kg的热量和约80g/d的脂
A large number of epidemiological studies have shown that the risk of colon cancer after cholecystectomy increased, especially in the proximal colon and women.Some studies of bile acid metabolism confirmed that patients with cholecystectomy in the enterohepatic circulation of secondary bile acids increased The aim of this study was to investigate the quantity and quality of the muscle acid in feces of patients with cholecystectomy so as to understand the contact between colonic mucosa and bile acid.Methods: 25 patients (5 males and 20 females) with an average of 60 years old undergoing cholecystectomy The average time of resection was 13.1 ± 2.0 years (average 14 years) .There were 26 non-cholecystectomy patients (12 males and 4 females) with an average age of 56. None of the study subjects had hepatobiliary disease except cholecystectomy , No one had gastrointestinal surgery.Patients were admitted to the hospital regular meals, daily average provide 30cal / kg of calories and about 80g / d fat