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消化道(包括胃、肠、胰)所分泌的多肽(或单胺)激素的主要功能之一即调节消化道的分泌与运动功能。一些激素的过多可致急慢性腹泻,如胃泌素、胆囊收缩素(CCK)、胰泌素、肠血管活性肽(VIP)、胰多肽(PP)、生长抑素(SRIH)及血清素等。随着生化学及免疫化学的进展,已发现多种新的消化道多肽激素,应用放免法及免疫组织化学法可精确诊断激素分泌性肿瘤,故近20年来胰岛内分泌肿瘤(PET)的发现显著增多,新的激素分泌性肿瘤综合征也渐被证实。已肯定的PET计有胰岛素瘤、胃泌素瘤、高血糖素瘤、VIP瘤、胰多肽瘤、SRIH瘤及多发性内分泌腺瘤病。这些PET由于其内分泌细胞均属于体内APUD细胞系统故被统称之为APUD瘤(Apudoma)。PET直径常在1～3cm间,局部症状常
One of the main functions of the polypeptide (or monoamine) hormone secreted by the digestive tract (including the stomach, intestine, and pancreas) is to regulate the secretion and motor function of the digestive tract. Excessive hormones can cause acute and chronic diarrhea, such as gastrin, cholecystokinin (CCK), secretin, intestinal vasoactive peptide (VIP), pancreatic polypeptide (PP), somatostatin (SRIH), and serotonin Wait. With the development of biochemistry and immunochemistry, a variety of new digestive tract polypeptide hormones have been discovered. Radioimmunoassay and radioimmunoassay methods can accurately diagnose hormone-secreting tumors. Therefore, the discovery of pancreatic islet endocrine tumors (PET) has been significant in the past 20 years. Increased, new hormone secretory tumor syndrome has gradually been confirmed. Confirmed PET include insulinoma, gastrinoma, glucagonoma, VIP tumor, pancreatic polypeptide tumor, SRIH tumor, and multiple endocrine neoplasia. These PETs are collectively referred to as APUD tumors because their endocrine cells belong to the APUD cell system in vivo. PET diameter is usually between 1 ~ 3cm, local symptoms often