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目的:由于传统呼吸调控环路忽略了对血液循环的决定性作用,肺(静脉)血管容量相关研究甚少,亟需建立肺血管容量测量方法。方法:选择正常志愿者完成CT全肺扫描,图像数据经过计算机软件分析处理,从肺尖到肺底以40~50层进行肺野手工切划,相邻层间由计算机自动模拟连接,在去除干扰后进行全肺血管(≥0.6 mm)高精度三维立体成像技术处理,进而计算全肺和肺血管容积。结果:12例正常志愿者从肺尖到肺底CT扫描图片层数为530±98(431~841)张。全肺和肺血管的总容积是3705±857(2398~5383)ml,肺血管血液总的容积是125±32(94~201)ml。按肺静脉系统血管容量约为全肺血管血液容量一半计算,应该是63±16(47~100)ml。结论:肺CT扫描数据分析三维立体成像建立肺血管容量无创测量方法精确可行。
OBJECTIVE: Because traditional respiratory control circuits ignore the decisive effect on blood circulation, little is known about pulmonary (venous) vascular capacity, and there is an urgent need to establish a method for the measurement of pulmonary vascular capacity. Methods: The normal volunteers were selected to complete CT whole lung scanning. The image data were analyzed by computer software. Lung lungs were manually cut from 40 to 50 layers from the apex of the lung to the bottom of the lung. The adjacent layers were automatically simulated and connected by computer. After the interference, the whole lung vessels (≥0.6 mm) were processed by high-precision three-dimensional imaging and the whole lung and pulmonary vascular volume were calculated. Results: The number of CT scan images from the apex of the lung to the bottom of the lung in the 12 normal volunteers was 530 ± 98 (431 ~ 841). The total volume of whole lung and pulmonary vessels was 3705 ± 857 (2398-583) ml and the total volume of pulmonary blood vessels was 125 ± 32 (94-201) ml. According to the pulmonary vascular system about half the capacity of the whole blood vessels of blood vessels calculated, it should be 63 ± 16 (47 ~ 100) ml. Conclusions: Noninvasive measurement of pulmonary vascular volume by 3D CT in lung CT scan data is accurate and feasible.