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目的探讨2型糖尿病(T2DM)患者踝臂指数(ABI)与颈动脉内中膜厚度(CIMT)的相关性及其影响因素。方法对我院住院或门诊就诊的350例不同病程的T2DM患者,检查其ABI、CIMT,血压、身高、体质量、腰围、臀围,空腹血糖(FPG)及餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、血脂、空腹胰岛素(FINS)及餐后2 h胰岛素(2 hINS)、尿清蛋白水平及眼底情况,计算体质指数(BMI)和腰臀比(WHR);并根据ABI将患者分为3组和7组,探讨T2DM患者ABI与CIMT的相关性及其影响因素。结果 T2DM患者ABI和CIMT呈负相关(r=-0.264,P<0.01)。以ABI为应变量,低密度脂蛋白胆固醇(LDL-C)、24 h尿清蛋白、FPG进入回归模型(P<0.05)。结论 T2DM患者ABI和CIMT有相关性,可作为了解动脉粥样硬化的初步筛查指标,ABI<1.11时动脉粥样硬化的检出率明显增高,ABI作为T2DM患者动脉粥样硬化的初步筛查指标时其切入值或应提高;尿清蛋白、LDL-C、FPG是T2DM患者ABI的独立影响因素。
Objective To investigate the relationship between ankle-brachial index (ABI) and carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) and its influencing factors. Methods The blood glucose, body mass, waist circumference, hip circumference, fasting blood glucose (FPG) and 2 h postprandial blood glucose (2 hPG) were measured in 350 patients with T2DM who were hospitalized or outpatient in our hospital. , Body mass index (BMI) and waist-to-hip ratio (WHR) were calculated according to ABI, HbA1c, serum lipids, fasting insulin and 2 h insulin, urinary albumin and fundus. Patients were divided into 3 groups and 7 groups, to explore the correlation between ABI and CIMT in T2DM patients and its influencing factors. Results There was a negative correlation between ABI and CIMT in T2DM patients (r = -0.264, P <0.01). With ABI as the dependent variable, low density lipoprotein cholesterol (LDL-C), 24 h urinary albumin and FPG entered the regression model (P <0.05). Conclusions There is a correlation between ABI and CIMT in T2DM patients, which can be used as a primary screening index to understand atherosclerosis. The detection rate of atherosclerosis is significantly higher in patients with ABI <1.11. ABI is the primary screening for atherosclerosis in T2DM patients Index cut-off value or should be increased; urinary albumin, LDL-C, FPG are independent factors of ABI in T2DM patients.