论文部分内容阅读
目的:研究短叶决明子对实验性高脂血症模型小鼠脂代谢的影响,为开辟短叶决明新的药用部位提供试验依据。方法:喂饲高脂饲料8周建立高脂血症小鼠模型,试验第9周起将试验动物分为空白对照组、模型对照组、阳性对照组及短叶决明子高、中、低剂量组,灌胃给药6周。在试验第8,11,14周末,测定各组小鼠血清中总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、谷丙转氨酶、谷草转氨酶的含量。结果:给药6周后,与模型对照组比较,短叶决明子各剂量组均能不同程度地降低小鼠血清中TC、TG、LDL-C含量,提高HDL-C含量,其中以短叶决明子高剂量作用效果最显著;短叶决明子对小鼠血清中ALT、AST的活性无显著的改善作用。结论:短叶决明子具有降低高脂血症模型小鼠血清中TC、TG的含量,提高HDL-C的含量,抑制LDL-C含量升高的作用,从而达到降低血脂水平的目的。
Objective: To study the effect of short-leaf cassia seed on lipometabolism in experimental hyperlipidemia mice and to provide experimental basis for the development of new medicinal parts of short-leaf cassia. Methods: The model of hyperlipidemia mice was established after being fed with high-fat diet for 8 weeks. The experimental animals were divided into blank control group, model control group, positive control group and short-stalk cassia seed high, medium and low dose groups , Gavage for 6 weeks. The serum TC, TG, HDL-C and LDL-C of the mice in each group were measured at the end of the 8th, Alanine aminotransferase, aspartate aminotransferase content. Results: Compared with the model control group, the contents of TC, TG and LDL-C in the serum of the mice of the short-stalk cassia seed were decreased 6 weeks after the administration, and the levels of HDL-C were increased. Among them, High-dose effect of the most significant; short-leaf cassia seed serum ALT, AST activity no significant improvement. Conclusion: Short-leaf cassia seed can reduce the content of TC and TG, increase the level of HDL-C and inhibit the increase of LDL-C in mice with hyperlipidemia, so as to reduce the level of blood lipid.