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目的观察噻托嗅胺粉雾剂对重度稳定期慢性阻塞性肺疾病(COPD)患者肺功能的影响。方法 50例重度COPD患者,随机分为实验组和对照组,各25例。两组均给予吸氧、抗炎、平喘、解痉基础治疗。实验组使用噻托嗅胺粉雾剂吸入,对照组给予沙丁胺醇吸入,治疗1年。对两组患者的肺功能指标进行对比分析。结果实验组患者治疗前后FEV1、FEV1/预计值%、FEV1/FVC%比较差异具有统计学意义(P<0.05);对照组患者治疗前后FEV1、FEV1/预计值%、FEV1/FVC%比较差异无统计学意义(P>0.05)。治疗后两组比较差异有统计学意义(P<0.05)。结论噻托嗅胺粉雾剂治疗重度COPD稳定期,特别是A型患者,效果更好,能改善患者肺功能,值得在临床中推广使用。
Objective To observe the effect of tiotropium powder inhaler on pulmonary function in patients with severe chronic obstructive pulmonary disease (COPD). Methods Fifty patients with severe COPD were randomly divided into experimental group and control group, with 25 cases in each. Both groups were given oxygen, anti-inflammatory, antiasthmatic, spasm-based treatment. The experimental group inhaled tiotropium powder aerosol inhalation, the control group was given salbutamol inhalation for 1 year. The lung function of two groups of patients were compared. Results Before and after treatment, FEV1, FEV1 / predicted value and FEV1 / FVC% of the experimental group were significantly different (P <0.05). The difference of FEV1, FEV1 / predicted value and FEV1 / FVC% Statistical significance (P> 0.05). After treatment, the difference between the two groups was statistically significant (P <0.05). Conclusions Tiotropium powder inhaler is effective in the treatment of severe COPD, especially in type A patients. It can improve lung function and is worth popularizing in clinic.