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在1950年前对全身性(深部)真菌感染缺乏安全有效的治疗方法,对皮肤真菌病的治疗仅为传统经验的局部制剂,如水杨酸、十一烯酸及过锰酸钾等。灰黄霉素虽发现于1939年,但仅于20年后,当其显示对一些皮肤真菌在体外及临床有效时,才认识其重要性。本品口服给药后经肠道吸收,并选择性地浓集于角质层组织;对浅部真菌感染,包括指(趾)甲、毛发和皮肤癣病尤其有效。芳香二胺类,诸如羟乙磺酸丙氧苯脒、芪
The lack of a safe and effective treatment for systemic (deep) fungal infections by 1950 had resulted in the treatment of dermatophytosis as only traditionally experienced topical preparations such as salicylic acid, undecylenic acid and potassium permanganate. Griseofulvin was found in 1939, but only after 20 years did it recognize its importance when it appeared to be effective in vitro and clinically for some dermatophytes. This product is administered orally and is absorbed via the intestine and selectively accumulates in the stratum corneum tissue. It is especially effective for superficial fungal infections including nail, hair and dermatophytosis. Aromatic diamines, such as propoxypyridazine isethionate, stilbene