端粒酶在肿瘤的发生和发展中起重要的作用。端粒酶催化亚基单位也称为人端粒酶逆转录酶 ,是端粒酶激活的限速因素。对端粒酶催化亚基单位的调节主要在转录水平 ,通过对其启动子的调控 ,一些转录因子如 c-myc蛋白、Mad1、SP1、wt P5 3、人类乳头状瘤病毒 16型 E6癌蛋白、WT1及 E2 F等对 HTERT的表达起着调节作用 Telomerase plays an important role in tumorigenesis and development. The unit of telomerase catalytic subunit, also known as human telomerase reverse transcriptase, is the rate-limiting factor of telomerase activation. The regulation of the telomerase catalytic subunit unit is mainly at the transcriptional level through the regulation of its promoter, transcription factors such as c-myc, Mad1, SP1, wt P5 3, human papillomavirus type 16 E6 oncoprotein , WT1 and E2 F play a regulatory role in the expression of HTERT