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目的：比较地尔硫与复方降压片对高血压病左室肥大（ＬＶＨ）及心功能的影响。方法：高血压病伴ＬＶＨ７１例，随机单盲法分为２组。地尔硫组３６例，给地尔硫片６０ｍｇ，ｐｏ，ｔｉｄ×４８ｗｋ；对照组用复方降压片２片，ｐｏ，ｔｉｄ×４８ｗｋ。以多普勒超声心动图评定ＬＶＨ与心功能的变化。结果：２组血压均显著下降（Ｐ＜０．０１），组间比较，Ｐ＞０．０５；地尔硫组ＬＶＨ、左室舒张功能及血液流变学各指标均有显著改善（Ｐ＜０．０１），对照组无上述效应，组间比较，Ｐ＜０．０１。结论：地尔硫对高血压病左室肥厚及心功能的疗效优于复方降压片。
Objective: To compare the effects of diltiazem and compound antihypertensive tablets on left ventricular hypertrophy (LVH) and cardiac function in hypertensive patients. Methods: Hypertensive patients with LVH 71 cases were randomly divided into two groups. Diltiazem group 36 cases, to diltiazem tablets 60mg, po, tid × 48wk; control group with compound antihypertensive tablets 2, po, tid × 48wk. Assessment of LVH and cardiac function by Doppler echocardiography. Results: The blood pressure decreased significantly in both groups (P <0.01), P> 0.05 between groups; LVH, left ventricular diastolic function and hemorrheological indexes in Diltiazem group were significantly improved (P <0.01). There was no such effect in the control group, P <0.01. Conclusion: Diltiazem is superior to compound antihypertensive tablets in hypertensive left ventricular hypertrophy and cardiac function.