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目的 :探究产妇在分娩过程中应用催产素及不同剂量的催产素对新生儿高胆红素血症的影响,为临床提供指导意见。方法 :选取来我院出生的足月健康新生儿339例作为研究对象,按照分娩过程中是否使用催产素分为两组,未使用催产素的223例新生儿作为对照组,使用催产素的116例新生儿作为观察组,全部新生儿出生后第3、5、7天检测新生儿胆红素变化情况,在出生7d后记录新生儿高胆红素血症及窒息发生率。结果 :对照组出生后血胆红素值存在显著差异,与出生后3d比,出生后5d无差异,出生后7d显著降低,观察组出生后血胆红素值存在显著差异,与出生后3d比,出生后5d存在显著差异,出生后7d显著降低,两组间在出生后3d、5d、7d血胆红素值存在显著差异;在出生后3d,不同剂量催产素组间血胆红素值存在差异,5IU组和10IU组显著高于1.5IU组和2.5IU组,在出生后5d和7d,不同剂量催产素组间血胆红素值存在差异,随着剂量增加,血胆红素值显著升高;在高胆红素血症发生率上,对照组新生儿为21.97%(49/223),观察组新生儿为37.93%(44/116),存在显著差异;在窒息发生率上,对照组新生儿为4.04%(9/223),观察组新生儿为14.66%(17/116),存在显著差异。结论 :孕妇分娩时使用催产素可是新生儿高胆红素血症的高危因素,剂量越大,血胆红素升高越明显。
Objective: To investigate the effects of oxytocin and different doses of oxytocin on neonatal hyperbilirubinemia during labor, and provide guidance for clinical application. Methods: A total of 339 full-term healthy newborns born in our hospital were selected as the research object. According to whether or not oxytocin was used during labor, 223 newborns without oxytocin were used as the control group and oxytocin 116 Cases of newborns as observation group, all newborns on the 3rd, 5th, 7th day after birth to detect changes in neonatal bilirubin, 7d after birth record of neonatal hyperbilirubinemia and asphyxia incidence. Results: The levels of blood bilirubin in the control group after birth were significantly different from those at 3 days after birth, 5 days after birth and 7 days after birth. The levels of blood bilirubin in the observation group after birth were significantly different from those at 3 days after birth There was a significant difference between the two groups on the 5th, 5th and 7th day after birth, and there was a significant difference between the two groups on the 7th day after birth. At 3d days after birth, serum bilirubin There was a significant difference between the 5IU group and the 10IU group and the 1.5IU group and the 2.5IU group. There was a significant difference in blood bilirubin levels between different doses of oxytocin 5d and 7d after birth. With the increase of dosage, The incidence of hyperbilirubinemia was 21.97% (49/223) in the control group and 37.93% (44/116) in the observation group. There was a significant difference in the incidence of asphyxia The control group had 4.04% (9/223) of newborns and 14.66% (17/116) of newborns in the observation group, showing significant differences. Conclusion: The use of oxytocin in pregnant women during childbirth may be a risk factor for neonatal hyperbilirubinemia. The greater the dosage, the more obvious the increase of serum bilirubin.