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肿瘤干细胞是具有自我更新能力并能发展成为不同分化程度的肿瘤的一类细胞,它的存在是肿瘤转移和复发的重要原因。最新研究表明,肿瘤干细胞可通过肿瘤细胞的上皮–间充质化(epithelial-mesenchymal transition,EMT)产生。作为研究细胞调控的热点—非编码RNA,通过调控EMT可能会促使肿瘤细胞获得肿瘤干细胞特征。该文主要综述了近年来非编码RNA调控肿瘤细胞EMT以及干性获得的研究进展,以有助于理解肿瘤中非编码RNA的调控机制和功能。
Tumor stem cells are a type of cells with self-renewal ability and can develop into tumors with different degrees of differentiation. Its existence is an important reason for tumor metastasis and recurrence. Recent studies show that tumor stem cells can be produced by the epithelial-mesenchymal transition (EMT) of tumor cells. As a hot spot in the study of cell regulation - non-coding RNA, tumor cells may be induced to acquire tumor stem cell characteristics by regulating EMT. This review summarizes the research progress of non-coding RNAs regulating EMT of tumor cells and their availability in recent years to help understand the regulatory mechanisms and functions of non-coding RNA in tumors.