子痫前期是严重危害母婴健康的并发症。其确切发病机制不清,研究显示母胎免疫耐受不全是子痫前期发病的重要机制,孕激素是维持妊娠的重要激素,有免疫调节、抗炎等作用,提示孕激素对子痫前期可能有保护作用。本文介绍了孕激素与子痫前期相关性的研究进展,希望对临床研究有一定的指导作用。 Preeclampsia is a serious complication of maternal and child health. The exact pathogenesis is unclear, studies have shown that maternal fetal immune tolerance is an important pathogenesis of preeclampsia, progesterone is an important hormone to maintain pregnancy, immune regulation, anti-inflammatory effect, suggesting that progesterone may have preeclampsia Protective effects. This article describes the progesterone and preeclampsia research progress, hoping to have some guidance for clinical research.