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为了研究恶性肿病患者术前细胞免疫功能的变异情况，为临床治疗和麻醉处理提供一定的依据，选择肺癌、乳腺癌、肝癌、胃癌、肠癌和子宫内膜癌等六种常见恶性肿瘤患者共１１６例，于术前一周内分别用ＡＰＡＡＰ桥联酶标技术和５１Ｃｒ－释放试验检测他们外周血的Ｔ淋巴细胞亚群（ＴＬＳ）水平和自然杀伤细胞（ＮＫＣ）活性，并与１８例健康人相比较，用ｔ检验进行统计学处理。结果：各组ＣＤ３、ＣＤ４及ＣＤ４／ＣＤ８比值均显著低于对照组（Ｐ＜０．０５，Ｐ＜０．０１），ＣＤ８均显著高于对照组（Ｐ＜０．０１）；各组ＮＫＣ活性均有下降，除肠癌组外其余各组均显著低于对照组（Ｐ＜０．０５，Ｐ＜０．０１）。结果提示这些患者术前均已存在显著的细胞免疫功能紊乱，尤以免疫抑制及自身免疫监视能力下降尤为显著；主张术前应采用免疫疗法，力争在细胞免疫功能有所恢复后再接受麻醉手术，对提高疗效，减少并发症具有重要的临床意义。
In order to study the variation of preoperative cellular immune function in patients with malignant tumors and provide a basis for clinical treatment and anesthesia treatment, six common malignancy patients including lung cancer, breast cancer, liver cancer, gastric cancer, colorectal cancer, and endometrial cancer were selected. A total of 116 patients were assessed for their peripheral blood T-lymphocyte subsets (TLS) levels and natural killer cell (NKC) activity by APAAP bridging and 51Cr-release tests within one week before surgery, and 18 patients were healthy. Compared with humans, t-test was used for statistical analysis. Results: The ratios of CD3, CD4 and CD4/CD8 in each group were significantly lower than those in the control group (P<0.05, P<0.01), and CD8 was significantly higher than that in the control group (P<0.01); The activity decreased, except for the colorectal cancer group, all other groups were significantly lower than the control group (P<0.05, P<0.01). The results suggest that these patients have already had significant cellular immune dysfunction before surgery, especially in immunosuppression and autoimmune surveillance. It is advocated that immunotherapy should be used before surgery to strive for recovery after cellular immune function is restored. It has important clinical significance for improving curative effect and reducing complications.