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目的:研究单次静注注射用尖吻蛇毒血凝酶(HCA)的人体药代动力学规律。方法:30例男性健康志愿者随机分组至1 U、2 U、4 U 3个剂量组,每组10例,采用放射免疫分析法对受试血清检测HCA的含量,用DAS软件计算其药代动力学参数。结果:受试者给药后,药-时曲线符合二室模型,主要药代动力学参数:t1/2α为34～55 min;t1/2β为301～351 min;CL分别为0.001 1、0.001 2、0.000 9 L/(min.kg),Vd分别为1.357 0、0.593 4、0.410 1 L/kg,AUC0-tn分别为16 518.38、22 405.67和29 531.41μU/(min.ml),呈明显的剂量依赖关系。结论:单次静注注射用HCA体内药代动力学特征符合一级线性动力学二室模型。
Objective: To study the pharmacokinetics of HCA in a single intravenous injection. Methods: Thirty male healthy volunteers were randomly divided into three groups: 1 U, 2 U and 4 U, 10 in each. Radioimmunoassay was used to detect the content of HCA in the tested serum. Kinetic parameters. RESULTS: After administration, the pharmacokinetic-time curve was in accordance with the two-compartment model. The main pharmacokinetic parameters were t1 / 2α for 34-55 min, t1 / 2β for 301-351 min, CL for 0.001 and 0.001 The values of AUC0-tn were 16 518.38,22 405.67 and 29 531.41μU / (min.ml) respectively, which were obviously The dose-dependent relationship. Conclusion: The pharmacokinetics of HCA in single intravenous injection conforms to the first-order linear dynamic two-compartment model.