论文部分内容阅读
目的探讨三阴性乳腺癌(triple negative breast cancer,TNBC)的相关危险因素及临床病理学特征。方法 210例乳腺癌患者,70例TNBC患者为观察组,140例非TNBC患者为对照组,比较2组一般资料,分析TNBC的危险因素以及临床病理学特征。结果 2组年龄、体质量指数、泌乳情况、使用避孕药以及产次比较差异均有统计学意义(P<0.05);多因素logistic回归分析显示,体质量指数>25kg/m~2(OR=9.604,95%CI:3.670~89.237,P=0.002)、抑制泌乳(OR=9.00,95%CI:1.070~75.668,P=0.043)、使用避孕药(OR=13.280,95%CI:3.322~113.423,P=0.006)是TNBC发生的危险因素;TNBC主要表现为进展期浸润性导管癌,且具有更高的T、M分期。结论肥胖、抑制泌乳以及口服避孕药是女性TNBC发生的危险因素,TNBC恶性程度高于非TNBC。
Objective To investigate the risk factors and clinicopathological features of triple negative breast cancer (TNBC). Methods Totally 210 breast cancer patients and 70 TNBC patients were selected as observation group and 140 non-TNBC patients as control group. The general data of two groups were compared to analyze the risk factors and clinicopathological features of TNBC. Results There were significant differences in age, body mass index, lactation status, contraceptive use and parity among the two groups (P <0.05). Multivariate logistic regression analysis showed that body mass index> 25kg / m ~ 2 (OR = 13.280, 95% CI: 3.322-113.423, P = 0.043, 9.60, 95% CI: 3.670-89.237, P = 0.002) , P = 0.006) were the risk factors of TNBC. TNBC mainly showed advanced invasive ductal carcinoma with higher T and M stages. Conclusion Obesity, lactation suppression and oral contraceptives are the risk factors for TNBC in women. TNBC is more malignant than non-TNBC.